Dr. Andrew Terentis
Associate Professor
PhD: University of Sydney
BSc: University of Sydney
Research

Research in the Terentis lab aims to develop an understanding of the structure and function of biomolecules, living cells, and biological tissues through the application of Raman spectroscopy and microscopy as well as other optical spectroscopic techniques.  Specific research projects in the laboratory include:

Confocal Raman Microscopy Analysis of Skin Cancers
Confocal Raman microscopy (CRM) is applied to the study of single, living skin cancer cells as well as skin tissue specimens in order to determine the biochemical characteristics of skin cancers and to develop CRM as a tool for clinical diagnoses.

Function and Regulation of Indoleamine 2,3-Dioxygenase (IDO)
A range of optical spectroscopy techniques are employed, including resonance Raman, CRM, circular dichroism and UV-Visible absorption, as well as enzyme kinetic measurements to determine the mechanisms of inhibition of IDO by small-molecule inhibitors.

Structure-Function Studies of Cell-Penetrating Peptides
The interactions of cell-penetrating peptides with living cells are studied with CRM and fluorescence microscopy.  The secondary structures of CPPs in various solvent environments are further characterized by polarized Raman spectroscopy and CD.  Experimental measurements are supported by computational studies of peptide structure.

Structural Studies of G-quadruplexes
The structure of G-rich oligonucleotides that have the potential to form G-quadruplexes are studied with a variety of optical spectroscopic techniques, including polarized Raman, surface-enhanced Raman (SERS), CD, UV-Visible absorption, and fluorescence spectroscopy.
Department of Chemistry & Biochemistry
Dr. Evonne M. Rezler
Dr. Jerome E. Haky
Assistant Scientist
PhD: University of Sydney
BSc: University of Sydney
Research

My main research interests are in chemical education, involving the adaptation and incorporation of novel and green chemistry as well as spectroscopy-based research into the undergraduate chemistry curriculum. The goal being to enhance active student participation and engagement in their learning process.  I am also working on strategies to assess the outcomes for student learning as a result of the implementation of these innovations.

My biomolecular research interests focus on:

1. the development and application of spectroscopic techniques to investigate mechanisms of delivery and up-take of cell penetrating peptides (CPPs) and other potential drug carriers into live cells.

2. the study of the roles of secondary DNA structures (such as G-quadruplexes) in mediating cancer onset (and aging) in oncogene promoter regions and telomeres. The biological roles of secondary structures of RNA based molecules (e.g. siRNA and ribozymes) in the human body are also of great interest and very amenable to study using various spectroscopic techniques.
Associate Professor and Interim Chair
PhD: Case Western Reserve
BS: Cleveland State University
Research

Structure-activity relationships in gas and liquid chromatography


Alumina-based chromatographic stationary phases


Aluminum phosphonate complexes in solution and in the solid state


Organometallic polymers as selective adsorbents


New methods for analysis of proteins, peptides and other biological compounds.
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