Associate Scientist Department of Chemistry and Biochemistry Ph.D. Florida Atlantic University, 2009 Contact Information Office: PS 336A Phone: 561-297-4972 Email: email@example.com
My research aims to understand the role of oxidative stress on aging and age-related diseases. Oxidative stress plays a significant role in the pathogenesis of many age-related diseases including cancer, cardiovascular disease, Alzheimer’s disease and retinal diseases. Current research goals are to:
Investigate alterations in metabolic pathways in response to oxidative stress
Develop therapeutic strategies to modulate oxidative stress response for disease prevention and
Understand inter-relationship between mitochondrial function/dysfunction and aging.
Gurkar AU, Robinson AR, Li X, Allani SK, Webster A, Muravia M, Fallahi M, Weissbach H, Robbins PD, Croix CM, Niedernhoffer L, Gill MS. (2018) Dysregulation of DAF-16/FOXO3 –mediated stress responses accelerates oxidative DNA damage induced aging. Redox Biol. Sep; 18: 191-199. PMID: 30031267
Allani SK, Weissbach H, Lopez Toledano MA (2018) Sulindac induces differentiation of glioblastoma stem cells making them more sensitive to oxidative stress. Neoplasma 65: 376-388. PMID: 29788733.
Sur A, Kesaraju S,* Prentice H, Ayyanathan K, Baronas-Lowell D, et al. (2014) Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-alpha. Proc Natl Acad Sci U S A 111: 16754- 16759. (* equal contribution) PMCID: PMC4250171.
Ayyanathan K, Kesaraju S*, Dawson-Scully K, Weissbach H (2012) Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage. PLoS ONE 7: e39949. (*equal contribution). PMCID: PMC3398923.