Dr. Gregg B. Fields

Professor and Department Chair
Department of Chemistry and Biochemistry
Ph.D., Florida State University, 1988

Contact Information
Office: MC 211
Phone: (561) 799-8577
Email: fieldsg@fau.edu

Research Interests

Extracellular matrix biochemistry; synthetic protein design and construction; proteases of the extracellular matrix; cancer chemical biology; biomimetic biomaterials for drug delivery; tumor cell biology/signal transduction; solid-phase peptide synthesis methodology.

Recent Publications

Ivano Bertini, Marco Fragai, Claudio Luchinat, Maxime Melikian, Mirco Toccafondi, Janelle L. Lauer, and Gregg B. Fields. Structural Basis for Matrix Metalloproteinase 1-Catalyzed Collagenolysis. J. Am. Chem. Soc. 134, 2100-2110 (2012).

Maciej J. Stawikowski, Beatrix Aukszi, Roma Stawikowska, Mare Cudic, and Gregg B. Fields. Glycosylation modulates melanoma cell a2b1 and a3b1 integrin interactions with type IV collagen. J. Biol. Chem. 289, 21591-21604 (2014).

Lillian Onwuhu-Ekpete, Lisa Track, Anna Knapinska, Lyndsay Smith, Gaurav Kaushik, Travis LaVoi, Marc Giulianotti, Richard Houghten, Gregg B. Fields, and Dmitriy Minond. Novel Pyrrolidine Diketopiperazines Selectively Inhibit Melanoma Cells Via Induction of Late Apoptosis. J. Med. Chem. 57, 1599-1608 (2014).

Manishabrata Bhowmick, Roma Stawikowska, Dorota Tokmina-Roszyk, and Gregg B. Fields. Matrix Metalloproteinase Inhibition by Heterotrimeric Triple-Helical Peptide Transition State Analogs. ChemBiochem 16, 1084-1092 (2015).

Linda Cerofolini, Sabrina Amar, Janelle L. Lauer, Tommaso Martelli, Marco Fragai, Claudio Luchinat, and Gregg B. Fields. Bilayer membrane modulation of membrane type 1 matrix metalloproteinase (MT1-MMP) structure and proteolytic activity. Nat. Sci. Rep., in press (2016).

Awards and Recognition

McKnight-Land Grant Professorship, University of Minnesota, 1993-1995.

National Institutes of Health Research Career Development Award, 1994-1999.

Association of Biomolecular Resource Facilities Excellence Award in Peptide Synthesis Research, 1997.

Researcher of the Year Award (Full Professor), FAU, 2000-2001.

Profiled in Time Magazine 163(23), June 7, 2004, “The Secrets Of Their Success,” pg. 107-110.

Distinguished Visiting Professor, Imperial College London, 2004.

Researcher of the Year Award (Full Professor), FAU, 2005-2006.

Robert A. Welch Foundation Distinguished University Chair in Chemistry, UTHSCSA, 2008-2010.

Distinguished Chair of Metalloproteinase and Multiple Sclerosis Research, TPIMS, 2010-2014.

Arthritis & Chronic Pain Research Institute Lecturer, University of Florence, Italy, 2011.

Elected Fellow, National Academy of Inventors, 2014.

Elected Fellow, American Association for the Advancement of Science (AAAS), 2015.

Other Information

Member, American Chemical Society, 1986-present.

Editor-In-Chief, International Journal of Peptide Research and Therapeutics, 2004-present.

Editorial Board, Biopolymers (Peptide Science), 2004-present

Member, American Association for the Advancement of Science, 2011-present.

Member, American Cancer Society Peer Review Committee on Institutional Research Grants, 2012-2017.

Director, Center for Molecular Biology & Biotechnology, FAU, 2014-present.