Dr. Kate S. Carroll

Dr. Kate S. Carroll

Professor 
Department of Chemistry and Biochemistry
Ph.D., Stanford University, 2003

Contact Information
Office: MC-17, Room 104
Phone: (561) 799-8140
Email: kcarro14@fau.edu
Website

Research Expertise and Interests

Chemistry, molecular and cell biology, chemical biology, cancer, neurodegenerative disorders, drug discovery, chemoproteomics, sulfur metabolism

Selected Publications

Carroll, K. S. New frontiers in sulfur and selenium chemical biology. Curr. Opin. Chem. Biol. 2024

Fu, L., Jung, Y., Tian, C., Ferreira, R. B., Cheng, R., He, F., Yang, J. & Carroll, K. S. Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat. Chem. Biol. 2023 News & Views

Shi, Y. & Carroll, K. S. Redox chemical biology in Advanced chemical biology: Chemical dissection and reprogramming of biological systems , 1st edition. (Hang, H., Pratt, M. & Prescher J. ed.) Wiley-VCH: Weinheim, Germany, Chapter 20 (2023).

Ferreira, R. B., Fu., L., Jung, Y., Yang, J. & Carroll, K. S. Reaction-based fluorogenic probes for detecting protein cysteine oxidation in living cells. Nat. Comm. 2022

Shi, Y. & Carroll, K. S. Detection of the oxidation products of thiols: Disulfides, and sulfenic, sulfinic, and sulfonic acids in Redox chemistry and biology of thiols , 1st edition. (Alvarez, B., Comini, M. A., Salinas, G., Trujillo, M. ed.) Elsevier: Oxford, United Kingdom, Chapter 7 (2022).

Shi, Y., Zelda, A., Edwards, C. E., Mallory, M. L., Sastre, S., Machado, M. R., Pickles, R. J., Fu, L., Liu, K., Yang, J., Baric, R. S., Boucher, R. C., Radi, R. & Carroll, K.S. Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 through allosteric disulfide disruption in the spike glycoprotein. Proc. Natl. Acad. Sci. U.S.A. 2022

Shi, Y., Fu. L., Yang, J. & Carroll, K. S. Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting. Nat. Chem. 2021

Google Scholar

Major Research Directions

  1. Chemoproteomics-enabled covalent ligand discovery platforms to tackle the redox proteome or “redoxome”
  2. Expanding the scope of thiol-based redox regulation using chemoproteomic platforms
  3. Discovering redox-based therapeutic modalities

Select Awards

Pfizer Award in Enzyme Chemistry, 2013

Camile Dreyfus Teacher-Scholar Award, 2010

Other Information

Chair, ACS Division of Biological Chemistry, Program Committee, 2024

Vice Chair, ACS Division of Biological Chemistry, Program Committee, 2023

Member, ACS Division of Biological Chemistry, Program Committee, 2022

Chair, Thiol-Based Redox Regulation and Signaling, Gordon Research Conference, 2022

Fellow, The Royal Society of Chemistry, 2022

Associate Editor, Free Radical Biology and Medicine, 2021

Vice Chair, Thiol-Based Redox Regulation and Signaling, Gordon Research Conference, 2018