Dr. Mare Cudic

Research Interests

The main emphasis of our research is to better understand protein-carbohydrate interactions involved in many important physiological and pathological processes. We use chemical approaches to synthesize model glycopeptides and glycopeptide libraries as tools for probing glycan biology. This research may have implications in the development of novel more effective disease-modifying therapeutic strategies for cancer and neurodegenerative diseases such as Alzheimer’s disease.

 

Awards and Recognition

2024    The Researcher of the Year, College of Science, FAU

2023    The Distinguished Mentor of the Year Award, FAU

2019    The Distinguished Mentor of the Year Award, College of Science, FAU

 

Recent publications: GoogleScholar PubMed

1. Vela Navarro, G. De Nadai Mundim, M. Cudic (2025) “Implications of Mucin-Type O-Glycosylation in Alzheimer's Disease.” Molecules, 30:1895. https://pmc.ncbi.nlm.nih.gov/articles/PMC12073284/
   
   
2. Ayyalasomayajula,I. Boneva, D. Ormaza, A. Whyte, Jr., K. Farook, Z. Gorlin, E. Yancey, S. André, H. Kaltner, and M. Cudic (2024) “Synthesis and Thermodynamic Evaluation of Sialyl-Tn MUC1 Glycopeptides Binding to Macrophage Galactose-Type Lectin.” ChemBioChem, e202400391. https://pubmed.ncbi.nlm.nih.gov/38877657/
   
   
3. Ayyalasomayajula,and M. Cudic (2024) “Targeting Siglec-Sialylated MUC1 Immune Axis in Cancer.” Cancers (Basel), 16:1334.https://pmc.ncbi.nlm.nih.gov/articles/PMC11011055/
   
   
4. Singh, D. Regmi, D. Ormaza, R. Ayyalasomayajula, N. Vela, G. Mundim, D. Du, D. Minond, and M. Cudic (2022) “Mucin-type O-Glycosylation Proximal to β-Secretase Cleavage Site Affects APP Processing and Aggregation Fate.” Front. Chem., 10:859822. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023740/
   
   
5. M. Beckwith, F. G. FitzGerald, M. C. Rodriguez Benavente, E. R. Mercer, A. K. Ludwig, M. Michalak, H. Kaltner, J. Kopitz, H.-J. Gabius, M. Cudic (2021) “Calorimetric Analysis of the Interplay between Synthetic Tn Antigen-Presenting MUC1 Glycopeptides and Human Macrophage Galactose-Type Lectin.”, Biochemistry, 60:547-558. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269692/
   
   
6. Singh, D. Ormaza, A. Massetti, D. Minond, and M. Cudic (2021) “Tyrosine O-GalNAc Alters the Conformation and Proteolytic Susceptibility of APP Model Glycopeptides.” ACS Chem. Neurosci., 12:2974-2980. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378340/
   
   
7. Singh, M. C. Rodriguez Benavente, M. H. Al-Huniti, D. Beckwith, R. Ayyalasomayajula, E. Patino, W. S. Miranda, A. Wade, and M. Cudic (2020) “Positional Scanning MUC1 Glycopeptide Library Reveals the Importance of PDTR Epitope Glycosylation for Lectin Binding.” J. Org. Chem. 85:1434-1445. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012140/
   
   
8. G. FitzGerald, M. C. Rodriguez Benavente, C. Garcia, Y. Rivero, Y. Singh, H. Wang, G. B. Fields, M. Cudic (2020) “TF-containing MUC1 glycopeptides fail to entice Galectin-1 recognition of tumor-associated Thomsen-Freidenreich (TF) antigen (CD176) in solution.” Glycoconj. J. 37:657-666. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680447/
   
   
9. M. C. Rodriguez, S. Yegorova, J-P. Pitteloud, A. E. Chavaroche, S. André, A. Ardá, D. Minond, J. Jiménez-Barbero, H-J. Gabius,and M. Cudic (2015) “Thermodynamic switch in binding of adhesion/growth-regulatory human galectin-3 to tumor-associated TF antigen and MUC1 glycopeptides.” Biochemistry,  54:4462-74. http://pubs.acs.org/doi/abs/10.1021/acs.biochem.5b00555
   
   
10. S. Yegorova, A. A. E. Chavaroche, M. C. Rodriguez, D. Minond, M. Cudic (2012) “Analysis of low affinity glycan-lectin interactions using AlphaScreen technology.” Anal Biochem. 439: 123-131. http://www.sciencedirect.com/science/article/pii/S0003269713002194

 

Other Information

Member Editorial Board, Frontiers in Chemistry, Chemical Biology

Member, National Certification Exam Committee, American Society for Biochemistry and Molecular Biology (ASBMB)

Member, American Chemical Society

Member, Society for Glycobiology

Member, American Peptide Society