Our research focuses on advancing the understanding of protein–carbohydrate interactions, which are fundamental to a wide range of physiological and pathological processes. We utilize chemical synthesis to design and construct glycopeptide models and glycopeptide libraries, which serve as versatile tools for probing the complexities of glycan biology. To characterize these interactions, we apply a variety of biophysical techniques, including isothermal titration calorimetry (ITC) and atomic force microscopy (AFM), enabling detailed analysis of their thermodynamic and kinetic profiles. This work aims to provide a critical foundation for translating insights into disease-associated glycan–protein interactions into the development of next-generation, disease-modifying therapies, particularly for cancer and neurodegenerative disorders such as Alzheimer’s disease.
